Compensation: Pay Range: $164,300.00 -$246,700.00 Location: Remote - U.S. We are seeking a Staff Software Engineer to help lead the design and development of the Java/Spring and React platform behind our precision genomics and clinical reporting products. This is a hands-on technical leadership role: you will set technical direction across multiple services, raise the engineering bar through design review and mentorship, and partner directly with scientific and clinical domain experts to build systems that are reliable, performant, and trusted in a regulated clinical environment Responsibilities: Architect, develop, and enhance Java/Spring and React applications supporting scientific workflows for variant identification, curation, ranking, and clinical reporting. Design and own data models, APIs, and search/query strategies that make large-scale genomic variant data fast and precise to filter, faceted, and retrieve at scale. Partner directly with scientific and clinical subject matter experts to translate complex domain requirements into clear, well-scoped technical designs. Lead design and development of scalable, maintainable, and secure solutions, and drive alignment on technical direction across teams through design docs and architecture reviews Troubleshoot complex production issues across the stack, resolve root causes, and measurably improve system reliability, observability, and performance. Use AI-assisted development tools effectively and responsibly to accelerate delivery, and help the team establish good practices for their use. Advocate for best practices in software engineering, code quality, automated testing, and CI/CD. Other duties as assigned. Required Education & Experience: Bachelor’s degree in computer science, Information Technology, or a related field or equivalent work experience 8+ years of experience in software engineering, with a focus on full-stack application development. Proven leadership experience, with the ability to lead by example and mentor engineers. Strong expertise in cloud-based solutions and experience integrating third-party software into existing systems. Extensive experience in building service-oriented architectures and designing RESTful API services to support scalable and maintainable applications. Excellent problem-solving skills with the ability to troubleshoot and resolve technical challenges efficiently. Effective communication skills, capable of articulating complex technical concepts to non-technical stakeholders. Experience with search and query technologies such as OpenSearch or Elasticsearch, including index and mapping design, query performance tuning, and faceted filtering over large datasets. Experience and familiarity working in Java / Spring, React. Experience working with relational databases (PostgreSQL, MySQL) and NoSQL technologies (OpenSearch/Elasticsearch, MongoDB, DynamoDB Preferred Experience: Master's degree Experience in scientific, genomics, or healthcare-related applications is a plus. Experience designing, developing, and deploying cloud-native applications on public cloud platforms such as AWS, Azure, or GCP PRIVACY NOTICES To review Ambry’s Privacy Notice, Click here: https://www.ambrygen.com/legal/privacy-policy To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics To review the UKG privacy notice, click here: California Privacy Notice | UKG Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.